Journal of Yeungnam Medical Science

Jae Sung Seo

14 Articles

Spinal Fusion Based on Ex Vivo Gene Therapy Using Recombinant Human BMP Adenoviruses.: Gi Beom Kim, Jae Ryong Kim, Myun Hwan Ahn, Jae Sung Seo; Yeungnam Univ J Med. 2007;24(2):262-274. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.262

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Abstract PDF: PURPOSE: Bone morphogenetic proteins (BMPs) play an important role in the formation of cartilage and bone, as well as regulating the growth of chondroblasts and osteoblasts. In this study, we investigated whether recombinant human BMP adenoviruses are available for ex vivo gene therapy, using human fibroblasts and human bone marrow stromal cells in an animal spinal fusion model. MATERIALS AND METHODS: Human fibroblasts and human bone marrow stromal cells were transduced with recombinant BMP-2 adenovirus (AdBMP-2) or recombinant BMP-7 adenovirus (AdBMP-7), referred to as AdBMP-7/BMSC, AdBMP-2/BMSC, AdBMP-7/HuFb, and AdBMP-2/HuFb. We showed that each cell secreted active BMPs by alkaline phosphatase staining. Since AdBMP-2 or AdBMP-7 tranducing cells were injected into the paravertebral muscle of athymic nude mice, at 4 weeks and 7 weeks, we confirmed that new bone formation occurred by induction of spinal fusion on radiographs and histochemical staining. RESULTS: In the region where the AdBMP-7/BMSC was injected, new bone formation was observed in all cases and spinal fusion was induced in two of these. AdBMP-2/BMSC induced bone formation and spinal fusion occurred among one of five. However, in the region where AdBMP/HuFb was injected, neither bone formation nor spinal fusion was observed. CONCLUSION: The osteoinductivity of AdBMP-7 was superior to that of AdBMP-2. In addition, the human bone marrow stromal cells were more efficient than the human fibroblasts for bone formation and spinal fusion. Therefore, the results of this study suggest that AdBMP-7/ BMSC would be the most useful approach to ex vivo gene therapy for an animal spinal fusion model.

An Epidemiologic Study of Low Back Pain of Women Working at a General Hospital.: Dong Gu Park, Myun Whan Ahn, Jong Chul Ahn, Sae Dong Kim, Jae Sung Seo; Yeungnam Univ J Med. 2007;24(2):186-196. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2.186

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BACKGROUND
The aim of this study was to confirm the risk factors for low back pain and injury to improve the prevention and treatment of lower back pain. MATERIALS AND METHODS: An epidemiologic study of low back pain and injury was performed with questionnaires distributed to 471 women working at Yeungnam university hospital. The differences in low back pain and injuries among various hospital departments were analyzed by a one-way analysis of variance (ANOVA), and the relevant factors included in the questionnaire were determined by a factor analysis. RESULTS: The frequency of low back pain in women in the department of diet and in the maintenance department was higher than among the other departments. The frequency of low back pain was mainly related to the frequency of psychosomatic symptoms. In addition, the low back pain was partially related to the frequency of psychosomatic symptoms and partially related to the frequency of pushing during the workday. The degree of disability from low back pain was increased by lifting and hard physical work and was related to the frequency of psychosomatic symptoms and the degree of work dissatisfaction. The frequency of low back injury was increased by increased standing time during work and hard physical work. The frequency of low back injury was related to advancing age and in part to psychosomatic symptoms. CONCLUSION: Lower back pain and its associated complications are related to psychosomatic factors and type of work. Lower back injury is related to physiological factors such as age. For the prevention and treatment of lower back pain, a multidisciplinary approach is required.

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Effects of the Hand Acupressure and Lumbar Strengthening Exercise on Women with Lower Back Pain
Eun Young Jeon
journal of east-west nursing research.2013; 19(2): 63. CrossRef

Calcifying Aponeurotic Fibroma: A Case Report.: Joon Hyuk Choi, Jae Sung Seo, Kil Ho Cho; Yeungnam Univ J Med. 2003;20(2):223-228. Published online December 31, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.2.223

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Abstract PDF

Calcifying aponeurotic fibroma is a rare benign soft tissue tumor that usually involves distal extremities in children and adolescents, especially the hands and feet. We report a case of calcifying aponeurotic fibroma arising in a 14-year-old boy who complained of right thumb mass. Surgical excision was performed. The resected specimen showed a 2.0x1.5 cm grayish white, fibrotic tissue. Histologic examination showed proliferation of fibroblastic cells with infiltrative growth pattern. Foci of calcification and chondroid differentiation were present.

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Calcifying Aponeurotic Fibroma of Leg Masquerading as Hemangioma in an Adolescent Male along with Review of Literature
Akriti Jindal, Gargi Kapatia, Manjit Kaur Rana, Rahul Sharma
Indian Journal of Surgical Oncology.2024; 15(1): 136. CrossRef
Calcifying Aponeurotic Fibroma of the Elbow - A Case Report -
Mee-Hye Oh, Eun Ah Jung, Ji Hye Lee, Hyun Deuk Cho, Jong Kyu Han, Yong-Koo Park
The Korean Journal of Pathology.2009; 43(1): 75. CrossRef

Current Concepts in Arthroscopic Treatment of Anterior Shoulder Instability.: Jae Sung Seo; Yeungnam Univ J Med. 2003;20(1):13-27. Published online June 30, 2003; DOI: https://doi.org/10.12701/yujm.2003.20.1.13

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Abstract PDF: In the past, the report of shoulder instability undergoing open shoulder stabilization had satisfactory outcomes of greater than 90%. However, the functional loss of open procedure is severe in abduction and external rotation especially. Current arthroscopic techniques for shoulder instability result in success rate equal to open surgical procedure when the labrum is properly fixed to the glenoid rim using suture anchors, the capsule is tightened, and associated bony and soft tissue pathology is addressed. The arthroscopic surgery facilitates the view within shoulder joint for more accurate diagnosis, reduces operating time, minimises postoperative pain, reduces operative morbidity, improves shoulder function, and provides the possibility to perform other procedure simultaneously. However, to accomplish a successful arthroscopic stabilization procedure and to prevent complications, numerous advanced arthroscopic skill must be mastered. Although the arthroscope provides means to visualize new lesions, the pathomechanism and biomechanical explanation is not clear yet. Further studies are necessary to develop for shoulder reconstruction.

Limb Lengthening.: Jae Sung Seo; Yeungnam Univ J Med. 1996;13(2):182-191. Published online December 31, 1996; DOI: https://doi.org/10.12701/yujm.1996.13.2.182

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Abstract PDF: No abstract available.

Histological Observation of Bone Reaction with Relation to Surface Treatment of Titanium.: Myun Whan Ahn, Yong Sug Choi, Jong Chul Ahn, Jae Sung Seo, Dong Chul Lee, Jae Hyuk Jang; Yeungnam Univ J Med. 1996;13(1):116-133. Published online June 30, 1996; DOI: https://doi.org/10.12701/yujm.1996.13.1.116

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Abstract PDF: The biocompatibility of the titanium has been estabilished through various experimental studies such as cell culture toxicity test, pyrogen test, mutagen test and others. In order to confirm biocompatibility after fabrication of titanium and to clarify the difference between the bone reaction after insertion of the lathed titanium rods and the bone reaction after insertion of the finished and polished rods, both rods were implanted into the proximal femur of a rabbit. Histologic reactions in the bone were observed according to the ASTM standards at the intervals of 6 weeks, 12 weeks and 26 weeks after implantation. The result were as follows In 6 weeks after implantation of lathed titanium rods, inflammatory reactions, such as minimal degree infiltration of polymorphonuclear leukocytes and lymphocytes were observed in all cases. This was thought to be caused by surgical trauma. However, inflammatory cell infiltration was not seen after implantation of polished and finished rods in all cases. The cellular infiltration and the histologic reaction of the bone after implantation of lathed group were significantly more pronounced than those after implantation of the finished group. In 12 weekt after implantation of lathed rods, two of four cases revealed a minimal degree of cellular infiliration and histologic reaction seemed to be more pronounced in the lathed group, but they were not significant statistically.

The clinical study of the supracondylar fracture of the femur.: Jong Chul Ahn, Se Dong Kim, Jae Sung Seo, Dong Chul Lee, Young Joo Lee; Yeungnam Univ J Med. 1993;10(1):197-211. Published online June 30, 1993; DOI: https://doi.org/10.12701/yujm.1993.10.1.197

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Abstract PDF: Recently, the Supracondyle fracture of the femur is so severe and comminuted that it is difficult to treat open reduction and rigid fixation sufficiently due to violent traffic accident and external forces. The associated injuries are accompanied variously. So compliactions of the supracondyle fractures 'including joint.. stiffness, delayed union, infection are serious. However development of internal implant and operation skill result in relatively satisfactory function than conservative management. The authors reviewed. 20 cases of the supracondyle fracture of the femur treated at Yeungnam University Hospital from 1989. Dec. To 1992. Jan. The results were as follows 1. The male was common(70%). The 2nd-4th decade was most(87%). 2. The most common cause of injuries was traffic accident. The rate of open fracture was 35%, most of it was traffic accident. 3. According to the ASIF group classification, 4 cases were type A, 4 in type B, 12 in type C (10 in type C2&C3). 4. Accompanied injuries included multiple fractures in 9 cases and femoral artery injury in 1 case. 5. Among the 20 cases, conservative treatment was done in 5 cases and operative treatment was done in 15 cases. 6. Functional results (by Schatzker criteria) were as follows. The satisfactory results were achieved in 40% of cases in consevative treatment and 67 in operative treatment. 7. The average time of partial weight bearing was 15 weeks. 8. Complications were knee stiffness in 6 cases and 4 in delayed union.

Treatment of the tibia shaft fractures with ender nails.: In Ki Kim, Dong Chul Lee, Jae Sung Seo, Myun Whan Ahn, Se Dong Kim, Jong Chul Ahn; Yeungnam Univ J Med. 1992;9(1):130-136. Published online June 30, 1992; DOI: https://doi.org/10.12701/yujm.1992.9.1.130

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Abstract PDF: Fractures of the tibial shaft are the most common among the long bone fractures, and have much difficulty in treatment due to their numerous complications. Thirty patients with fractures of the tibial shaft were treated with Ender nails under the image intensifier at the Department of Orthopedic Surgery, Yeungnam University Hospital from December 1986 to November 1991. The following results were observed. 1. The average age was 37.3 years and the number of male was three times of the female. The most common cause was traffic accident. 2. Twenty cases out of thirty one were closed fracture and the remaining 11 were open. The comminuted and segmental fractures were 18 (57.7%) in number and the most common fracture site was the middle one third (53%). 3. Average interval from injury to operation was 7.6 days and 19 cases showed associated injuries. 4. The mean duration of the bone union was 18.9 weeks and 2 cases showed the delayed union. 5. Twelve complications were noted such as shortening, varus deformity, delayed union, ankle motion limitation, nail irritation, and soft tissue infection.

A study of the cause of metal failure in treatment of femur shaft fracture: Fractographical and clinical analysis of metal failure.: Chun Bae Jeon, Jae Sung Seo, Jong Chul Ahn, Myun Whan Ahn, Joo Chyl Ihn; Yeungnam Univ J Med. 1990;7(1):81-93. Published online June 30, 1990; DOI: https://doi.org/10.12701/yujm.1990.7.1.81

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Abstract PDF: The author fractographically analyzed the cause of metal failure (the first time this procedure has been used for this metal failure) and also analyzed in clinically. In this study, I selected eight cases which have been analyzed fractographically. In all these cases, the analysis was done after treatment of metal failure of implants internally fixed to femur shaft fractures at the Department of Orthopedic Surgery, Yeung-Nam University Hospital during the six year period from May 1983 to September 1989. 1. Metal failure occurred in five dynamic-compression plates, one Jewett nail, one screw in Rowe plate, and one interlocking nail. 2. The clinical cause of metal failure was deficiency of medial buttes in five cases, incorrect position of implant in one case, and incorrect selection of implant in two cases. 3. The time interval between internal fixation and metal failure was four months in one case, between five months to twelve months in six cases, three years in one case. 4. The fractographically analytical cause of metal failure was ; first, impact failure, one case, second, fatigue failure, six cases, machining mark (stress riser), four case type: low consistent cyclic fatigue failure irregular cyclic fatigue failure third, stress corrosion crack, one case. 5. 316 L Stainless Steel has good resistance to corrosion. However, when its peculiar surface film is destroyed by fretting, it shows pitting corrosion. This is, perhaps, the main cause of metal failure. 6. It is possible that mechanical injury occurred in implants during the manufacturing of implants or that making a screw hole in the main cause of metal failure.

Clinical Study on Monteggia Fracture.: Jae Sung Seo; Yeungnam Univ J Med. 1987;4(2):131-138. Published online December 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.2.131

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Abstract PDF: In 1814, Giovanni Battista Monteggia first described two cased of fracture of proximal third of ulna with a dislocation of radial head, and this combined injury is now known as the Monteggia fracture. Despite its rarity, the importance of early recognition of dislocated radial head and correct treatment has been emphasized. Eight cases of Monteggia fracture were studied from March, 1984 to June, 1987. The results are as follows 1. Male patients were six and female were two. 2. The frequent cause of injury was fall down in four cases. 3. Bado type I accounted for 50%, type II for 12.5% and type III for 37.5%. 4. The level of ulna fracture was above upper one third of ulna in seven. 5. The common direction of dislocated radial head was anterior. 6. Two children and two adults were managed by closed reduction. 7. The results (by Bruce et al. criteria) were 3 excellent, 2 good, 1 fair and 2 poor. Four ulna fractures in adult were treated by open reduction and internal fixation using a semitubular plate.

Osteogenesis Imperfecta (Correction of Anterior Tibial Bowing): A case report.: Jae Sung Seo, Joo Chul Ihn; Yeungnam Univ J Med. 1987;4(1):157-163. Published online August 31, 1987; DOI: https://doi.org/10.12701/yujm.1987.4.1.157

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Abstract PDF: Osteogenesis imperfecta has been categorized as a heritable disorder of connective tissue affecting both bone and soft tissues and is characterized by fragility of bone, blue sclera, and deafness, less frequently by dentinogenesis imperfect and laxity of ligament. The goals of orthopedic management with osteogenesis imperfecta are the treatment of acute factures and long term rehabilitation in an effort to maintain ambulation. We report a case of osteogenesis imperfecta with anterior bowing of tibia which was successfully corrected by multiple osteotomies and intramedullary fixation by Sofield method and reviewed literatures.

Treatment of Carpal Scaphoid Fracture.: Won Jin Beck, Jae Sung Seo, Jong Chul Ahn, Joo Chul Ihn; Yeungnam Univ J Med. 1986;3(1):361-366. Published online December 31, 1986; DOI: https://doi.org/10.12701/yujm.1986.3.1.361

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Abstract PDF: Fracture of the carpal scaphoid bone is the most common fracture of the carpus. Unfortunately, nonunion are common since the symptoms do not alert patents to seek early medical treatment and the diagnosis is easily missed. Fracture of the scaphoid is a common condition whose management remains controversial. The conservative treatment has many complications, these include inability to word while in plaster, stiffness of the wrist afterwards, muscle wasting, weakness and malunion. So various operative treatments of scaphoid fracture have been developed. Open reduction by use of screws suggested by Maclaughlin first in 1954. In 1984 a new and simple operative technique has been developed to provide rigid internal fixation for all types of fractures of the scaphoid by T.J. Herbert. This involves the use of a double-treaded bone screw which provides good fixation that, after operation, a plaster cast in rarely required and most patients are able to return to work within a few weeks. Authors have experienced 10 cases of scaphoid fracture and accomplished good result in all cases by internal fixation using Herbert screw. The results are as follows Of these 10 fractures, 2 were fresh fractures and 8 were nonunions of scaphoid fracture. In nonunion cases, the time interval between fracture and operation was from 5 months to 5 years. The postoperative immobilization period was average of 4 weeks. Short period of immobilization achieved early functional recovery of the wrist. The bony unions in roentgenogram were seen from 3 months to 9 months after operation. In 2 cases the fracture gap was seen after 9 months. But in these cases the symptoms such as pain and range of motion of wrist were improved.

The Effect of Tension Band Wiring in the Treatment of the Olecranon Fracture.: Joo Chul Ihn, Jong Chul Ahn, Sae Dong Kim, Myun Whan Ahn, Jae Sung Seo; Yeungnam Univ J Med. 1985;2(1):59-63. Published online December 31, 1985; DOI: https://doi.org/10.12701/yujm.1985.2.1.59

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Abstract PDF: Treatment of the olecranon fractures by prolonged immobilization often results in limited elbow motion. With the use of tension band wiring, anatomical reduction was obtainable, and only a short period of immobilization was needed. We reviewed the cases of 17 patients who underwent surgical treatment of the olecranon fracture. All patients were treated by tension band wiring. In the overall series, we were able to obtain 53 percent excellent, 30 percent good, and 18 percent fair results.

A Clinical Analysis Femur Neck Fracture in Elderly Patients.: Joo Chul Ihn, Myun Hwan Ahn, Jae Sung Seo; Yeungnam Univ J Med. 1985;2(1):11-22. Published online December 31, 1985; DOI: https://doi.org/10.12701/yujm.1985.2.1.11

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Abstract PDF: Femur neck fracture is well known as one of the major death cause after trauma in elderly patients, and unsolved fracture due to its frequent association with complications such as avascular necrosis and nonunion. Through meticulous evaluation of the patient, hip and surgeon's experiences, reduction of mortality and morbidity as well as rapid recovery of the patient to the preinjury social and ambulatory status without local complications and revision after treatment is urgently needed. Many factors about this fracture in itself were noted, but we have analyzed 18 femur neck fracture of the patients older than 50 years preliminarily according to age, fracture pattern, osteoporosis, etiology and method of treatment with its delay in association with major complications especially avascular necrosis and nonunion. The results are as follows; 1. Of these 18 fractures, 11 were in females, 8 were caused by minor trauma such as slipdown accident and 4 were associated with definite osteoporosis according to the Sing's classification. 2. Fracture pattern of these 18 are undisplaced in 4, displaced subcapital in 11, displaced transcervical in 3. 11 fractures in the patients older than 60 year are composed of 3 undisplaced or impacted fractures and 8 displaced subcapital fractures. 3. These 18 fractures were treated by closed reduction and internal fixation with multiple pins in 13, and hemiarthroplasty in 4, but one was not treated to die after discharge from hospital. 4. Undisplaced or impacted fractures and 3 displaced transcervical fractures were not associated with any complications such as avascular necrosis or nonunion. But 4 of 6 displaced subcapital fractures were complicated by avascular necrosis, 3 of which were reduced in the varus position within 1 week, and the other was reduced in the good position on 1 week after trauma. There was no complication in 2 displaced subcapital fractures reduced in valgus position within 3 days after trauma. According to the above results, the prognosis of the femur neck fracture is dependent upon the fracture pattern and delay in its treatment. So it is inevitable to reduce the fracture in anatomical or valgus position as early as possible. But the arthroplasty may be needed in displaced subcapital fractures delayed for several days, with its reluction in extreme varus position or impossible and with preexisting disease in the same hip joint (total hip replacement).

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